Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA.
Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Arch Gynecol Obstet. 2022 Mar;305(3):589-596. doi: 10.1007/s00404-021-06197-2. Epub 2021 Aug 24.
Omentin-1 plays an important role in regulating insulin sensitivity outside pregnancy. As an adipokine derived from human placental and adipose tissue, it may be an important contributor in the biological pathway of gestational diabetes.
Omentin-1 was measured in a sub-cohort of 50 participants in the Omega study. We aimed to evaluate whether circulating maternal omentin-1 concentrations are associated with fasting serum glucose, insulin, HOMA-IR and maternal obesity as measured by body mass index (BMI) and subcutaneous and intra-abdominal fat thickness measurements in normoglycemic pregnant participants. We performed a subgroup analysis by BMI category.
Omentin-1 was negatively correlated with HOMA-IR and insulin and inversely associated with serum glucose concentration in the fully adjusted model (- 47%; slope per tertile increase in concentration - 0.19; P-trend 0.01). This association was significant in non-overweight/obese (< 25 kg/m) but not among overweight/obese (≥ 25 kg/ m) participants. The association with serum insulin was not significant in the fully adjusted model.
Circulating omentin-1 concentrations are inversely associated with serum glucose concentrations. Although the relevance of these findings remains to be elucidated, they may indicate a mechanism for the development of insulin resistance and gestational diabetes. Follow-up studies with larger sample sizes are warranted.
网膜素-1 在调节妊娠外的胰岛素敏感性方面发挥着重要作用。作为一种来源于人胎盘和脂肪组织的脂肪因子，它可能是妊娠糖尿病生物学途径中的一个重要贡献者。
在 Omega 研究的一个亚队列中测量了网膜素-1。我们旨在评估循环母体外周血网膜素-1 浓度是否与空腹血糖、胰岛素、HOMA-IR 以及通过 BMI 和皮下及腹内脂肪厚度测量来衡量的母体肥胖有关。我们按 BMI 类别进行了亚组分析。
在完全调整的模型中，网膜素-1 与 HOMA-IR 和胰岛素呈负相关，与血清葡萄糖浓度呈负相关（-47%；浓度每增加一个三分位数的斜率为-0.19；P 趋势 <0.01）。这种关联在非超重/肥胖（<25 kg/m）人群中显著，但在超重/肥胖（≥25 kg/m）人群中不显著。在完全调整的模型中，网膜素-1 与血清胰岛素之间的相关性不显著。
循环网膜素-1 浓度与血清葡萄糖浓度呈负相关。尽管这些发现的相关性仍有待阐明，但它们可能表明了胰岛素抵抗和妊娠糖尿病发展的一种机制。需要更大样本量的随访研究来进一步证实。
