Pediatrics, Dr. Josep Trueta Hospital, Girona, Spain.
Obesity (Silver Spring). 2011 Sep;19(9):1905-7. doi: 10.1038/oby.2011.198. Epub 2011 Jun 30.
Omentin-1 is a recently recognized adipokine primarily originating in visceral adipose tissue. We posited that circulating omentin-1 could be an early marker of metabolic dysfunction. To this end, we examined the associations between circulating omentin-1, body fat (bioelectric impedance), an endocrine-metabolic profile (homeostasis model assessment for insulin resistance (HOMA(IR)), serum lipids, high-molecular-weight (HMW) adiponectin and blood pressure (BP)) and family history of obesity and diabetes in asymptomatic prepubertal children (n = 161; 77 boys and 84 girls; age 7 ± 1 year) with a normal distribution of height and weight. Increased circulating omentin-1 was associated with a poorer metabolic profile, with relatively higher HOMA(IR), fasting triacylglycerol, BP and familial prevalence of diabetes (all P < 0.005 to P < 0.0001), and relatively lower fraction of HMW adiponectin (P < 0.005), whereas no relationship was found with body weight or fat or with family history of obesity. All these associations were independent of age, gender and fat mass. In conclusion, circulating omentin-1 may become a marker of metabolic dysfunction integrating insulin sensitivity, markers of adipose-tissue metabolism and BP as early as in prepubertal childhood.
网膜素-1 是一种最近被发现的主要来源于内脏脂肪组织的脂肪因子。我们假设循环中的网膜素-1 可能是代谢功能障碍的早期标志物。为此，我们研究了循环中网膜素-1与体脂（生物电阻抗）、内分泌代谢特征（胰岛素抵抗的稳态模型评估（HOMA(IR)）、血清脂质、高分子量（HMW）脂联素和血压（BP））以及肥胖和糖尿病家族史之间的关系在 161 名无症状青春前期儿童（77 名男孩和 84 名女孩；年龄 7 ± 1 岁）中，这些儿童的身高和体重分布正常。循环中网膜素-1 的增加与代谢特征较差有关，相对较高的 HOMA(IR)、空腹三酰甘油、BP 和糖尿病家族患病率（均 P < 0.005 至 P < 0.0001），以及相对较低的 HMW 脂联素分数（P < 0.005），而与体重或体脂或肥胖家族史无关。所有这些关联均独立于年龄、性别和脂肪量。总之，循环中的网膜素-1 可能成为代谢功能障碍的标志物，早在青春前期儿童中就整合了胰岛素敏感性、脂肪组织代谢标志物和 BP。
