Department of Endocrine and Metabolic Diseases, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr 7514763448, Iran.
Cytokine. 2012 May;58(2):295-9. doi: 10.1016/j.cyto.2012.02.005. Epub 2012 Mar 6.
It has been suggested that adipose-derived cytokines act as insulin sensitizers/insulin-mimetics and some others may induce insulin resistance. In order to elucidate the potential role of novel adipocytokines in the pre-diabetes states, circulating levels of novel adipocytokines were evaluated in first-degree relatives of subjects with type 2 diabetes mellitus (FDRs).
Serum omentin-1, adiponectin and retinol-binding protein 4 (RBP4) levels were measured in 179 subjects (90 glucose tolerant FDRs and 89 age- and sex-matched healthy controls) using enzyme-linked immunosorbent assay (ELISA) methods.
There was no significant difference between the two groups regarding serum RBP4 concentrations. However, serum omentin-1 (median [interquartile range], 6.18 [4.06-11.52]ng/ml versus 10.50 [4.30-20.60]ng/ml, p=0.004) and adiponectin (mean±SD, 10.07±4.0 μg/ml versus 20.66±8.12 μg/ml, p<0.0001) levels were significantly lower in FDRs when compared with the controls. In multiple logistic regression analysis, FDRs showed a significant association with lower circulating omentin-1 and adiponectin levels, even after adjustments were made for age, sex, body mass index, blood pressure measures, and biochemical parameters including glucose status, lipid profile, insulin levels and HOMA-IR (OR=0.49, CI [0.30-0.79]; p=0.004 and OR=0.74, CI [0.67-0.82]; p<0.0001, respectively). However, FDRs did not show a significant association with serum RBP4 levels in different models of regression analyses.
The FDRs showed significant associations with lower omentin-1 and adiponectin levels. A potential role for these adipokines in the FDRs' increased risk of diabetes needs to be further elucidated.
脂肪细胞因子可作为胰岛素增敏剂/胰岛素类似物，而另一些因子则可能导致胰岛素抵抗。为了阐明新型脂肪细胞因子在糖尿病前期状态中的潜在作用，我们评估了 2 型糖尿病患者一级亲属（FDRs）的循环新型脂肪细胞因子水平。
采用酶联免疫吸附法（ELISA）检测 179 例受试者（90 例糖耐量正常的 FDRs 和 89 例年龄和性别匹配的健康对照者）血清网膜素-1、脂联素和视黄醇结合蛋白 4（RBP4）水平。
两组间血清 RBP4 浓度无显著差异。然而，与对照组相比，FDRs 血清网膜素-1（中位数[四分位数间距]，6.18[4.06-11.52]ng/ml 与 10.50[4.30-20.60]ng/ml，p=0.004）和脂联素（均值±标准差，10.07±4.0μg/ml 与 20.66±8.12μg/ml，p<0.0001）水平显著降低。在多因素 logistic 回归分析中，即使在校正了年龄、性别、体重指数、血压测量以及包括血糖状态、血脂谱、胰岛素水平和 HOMA-IR 在内的生化参数后，FDRs 仍与较低的循环网膜素-1和脂联素水平显著相关（OR=0.49，CI [0.30-0.79]；p=0.004 和 OR=0.74，CI [0.67-0.82]；p<0.0001）。然而，在不同回归分析模型中，FDRs 与血清 RBP4 水平无显著相关性。
FDRs 与较低的网膜素-1和脂联素水平显著相关。这些脂肪细胞因子在 FDRs 中糖尿病风险增加中的潜在作用需要进一步阐明。
