Feng Yakai, Lu Jian, Behl Marc, Lendlein Andreas
School of Chemical Engineering and Technology, Tianjin University, Tianjin, China.
Int J Artif Organs. 2011 Feb;34(2):103-9. doi: 10.5301/ijao.2011.6402.
Polydepsipeptides, alternating copolymers of an a-amino acid and a a-hydroxy acid, are an interesting group of degradable polymers. They have gained attention as potential degradable implant materials. Polydepsipeptides are expected to have better biocompatibility in vivo during the degradation process than aliphatic polyesters. Various depsipeptide-based polymers with or without pendant functional groups have been synthesized via ring-opening polymerization of corresponding morpholine-2,5-dione derivatives. The different polymer architectures of the polymers, for example, providing an alternating, random, diblock, triblock, or multiblock structure, can be obtained by appropriate selection of the polymerization reaction, which may be ring-opening or polyaddition. Recently, we synthesized thermoplastic phase-segregated copolymers with a multiblock structure containing polydepsipeptides and poly(e-caprolactone) or poly(p-dioxanone) segments via coupling of the respective diols using an aliphatic diisocyanate. The obtained multiblock copolymers showed good elastic properties at 25 °C and 75 °C. Furthermore, they exhibited a shape-memory capability. Here, we summarize the synthesis, biodegradation behavior and shape-memory properties of the multiblock copolymers. In addition, we introduce new combinations of depsipeptide/poly(ether)ester segments in multiblock copolymers. The depsipeptide-based multiblock copolymers have potential applications as biomaterials for controlled drug release, tissue engineering scaffolds, or base materials for biofunctional implants.
聚二肽是α-氨基酸和α-羟基酸的交替共聚物，是一类有趣的可降解聚合物。它们作为潜在的可降解植入材料受到了关注。预计聚二肽在体内降解过程中的生物相容性比脂肪族聚酯更好。通过相应吗啉-2,5-二酮衍生物的开环聚合反应，已合成了各种带有或不带有侧链官能团的基于二肽的聚合物。通过适当选择聚合反应（可以是开环聚合或加聚反应），可以得到聚合物的不同结构，例如交替、无规、二嵌段、三嵌段或多嵌段结构。最近，我们通过使用脂肪族二异氰酸酯将各自的二醇偶联，合成了具有多嵌段结构的热塑性相分离共聚物，该多嵌段结构包含聚二肽和聚（ε-己内酯）或聚（对二氧六环酮）链段。所得到的多嵌段共聚物在25℃和75℃下表现出良好的弹性性能。此外，它们还具有形状记忆能力。在此，我们总结了多嵌段共聚物的合成、生物降解行为和形状记忆性能。此外，我们还介绍了多嵌段共聚物中二肽/聚（醚）酯链段的新组合。基于二肽的多嵌段共聚物作为用于控释药物、组织工程支架或生物功能植入物的基础材料的生物材料具有潜在的应用。
