Feng Yakai, Behl Marc, Kelch Steffen, Lendlein Andreas
Department of Polymer Science and Technology, Tianjin University, 92 Weijin Road, Tianjin 300072, China.
Macromol Biosci. 2009 Jan 9;9(1):45-54. doi: 10.1002/mabi.200800199.
Thermoplastic phase-segregated multiblock copolymers with polydepsipeptides and PCL segments were prepared via coupling of diol and PCL-diol using an aliphatic diisocyanate. The obtained multiblock copolymers showed good elastic properties and a shape memory. Almost complete fixation of the mechanical deformation, resulting in quantitative recovery of the permanent shape with a switching temperature around body temperature, was observed. In hydrolytic degradation experiments, a quick decrease of the molecular weight without induction period was observed, and the material changed from elastic to brittle in 21 d. These materials promise a high potential for biomedical applications such as smart implants or medical devices.
通过使用脂肪族二异氰酸酯将二醇与聚己内酯二醇偶联，制备了具有聚（二肽）和聚己内酯链段的热塑性相分离多嵌段共聚物。所获得的多嵌段共聚物表现出良好的弹性性能和形状记忆性能。观察到机械变形几乎完全固定，在体温左右的转变温度下导致永久形状的定量恢复。在水解降解实验中，观察到分子量迅速下降且无诱导期，并且该材料在21天内从弹性变为脆性。这些材料在智能植入物或医疗设备等生物医学应用方面具有很高的潜力。
