Ishaq Saliha, Khalil Sarwat, Khan Ayesha, Khalid Umair
Department of Medicine, Ziauddin University, Clifton, Karachi.
J Pak Med Assoc. 2010 Nov;60(11):975-6.
Anti-phospholipid syndrome (APS) can manifest as primary disease or secondary to connective tissue diseases, such as systemic lupus erythematosus (SLE). It is characterized by recurrent arterial or venous thrombosis, thrombocytopenia, haemolytic anaemia, or positive Coombs' test, and recurrent pregnancy loss in females. Common neurological abnormalities include stroke, cognitive deficits and white matter lesions. We present an unusual case of secondary APS associated with SLE, that presented at our clinic with chorea. To the best of our knowledge this is a first such case reported from Pakistan. APS must be ruled out in any patient of SLE who presents with stroke or any other neurological abnormality regardless of the age at presentation. Moreover, unusual neurological presentations, such as chorea, should always be kept in mind in order to promptly diagnose and treat APS owing to its high morbidity and mortality.
抗磷脂综合征（APS）可表现为原发性疾病，或继发于结缔组织病，如系统性红斑狼疮（SLE）。其特征为反复发生动脉或静脉血栓形成、血小板减少、溶血性贫血或库姆斯试验阳性，以及女性反复流产。常见的神经学异常包括中风、认知缺陷和白质病变。我们报告一例与SLE相关的继发性APS罕见病例，该病例在我们诊所表现为舞蹈症。据我们所知，这是巴基斯坦报道的首例此类病例。对于任何出现中风或任何其他神经学异常的SLE患者，无论其发病年龄如何，均必须排除APS。此外，由于APS的高发病率和死亡率，对于不寻常的神经学表现，如舞蹈症，应始终牢记于心，以便及时诊断和治疗APS。
