Fontenay M, Flandrin G, Baurman H, Loiseau P, Valensi F, Daniel M T, Sigaux F
Central Hematology Laboratory, Hôpital Saint-Louis, Paris, France.
Leukemia. 1990 Feb;4(2):100-5.
T cell receptor delta (TCR) genes have been recently identified as rearranging during the early stages of T cell differentiation. We have analyzed the configuration of these genes in 47 unselected acute nonlymphoid leukemias. Morphology, phenotype, immunoglobulin heavy chain, and T cell receptor beta and gamma chain gene configuration were also studied. We have documented TCR delta gene rearrangements or deletions in eight cases using a genomic J delta 1 probe. The comparison of morphological, phenotypical, and molecular findings from these cases with those from control acute myeloid leukemias whose TCR delta genes were in germline configuration show that TCR delta rearrangements occur predominantly in immature leukemia exhibiting extensive lineage infidelity. The most striking feature was the frequent expression of the CD10 antigen. These data show that inappropriate gene rearrangements occur nonrandomly in myeloid leukemias and suggest that common mechanisms may be involved in the regulation of gene rearrangements and in the expression of some differentiation antigens.
T细胞受体δ（TCR）基因最近被确定在T细胞分化的早期阶段发生重排。我们分析了47例未经选择的急性非淋巴细胞白血病中这些基因的构型。同时还研究了形态学、表型、免疫球蛋白重链以及T细胞受体β和γ链基因构型。我们使用基因组Jδ1探针在8例病例中记录到了TCRδ基因重排或缺失。将这些病例的形态学、表型和分子学发现与TCRδ基因处于种系构型的对照急性髓系白血病的发现进行比较，结果显示TCRδ重排主要发生在表现出广泛谱系不忠实的不成熟白血病中。最显著的特征是CD10抗原的频繁表达。这些数据表明，不适当的基因重排在髓系白血病中并非随机发生，提示基因重排的调控和某些分化抗原的表达可能涉及共同机制。
