Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA.
OMICS. 2011 Mar;15(3):133-9. doi: 10.1089/omi.2010.0111.
Currently available technologies allow in-depth analysis of multiple facets of the proteome that have clinical relevance and that complement current genomics-based approaches. Although some progress has been made in our knowledge of the human proteome in health and in disease, there is an urgent need to chart a coherent road map with clearly defined milestones to guide proteomics efforts. Areas of emphasis include: (1) building resources, (2) filling gaps in our understanding of biological variation, and (3) systematically characterizing proteome alterations that occur in well-defined disease states, all of which require an organized and collaborative effort.
目前可用的技术可以深入分析具有临床相关性且补充当前基于基因组学的方法的蛋白质组的多个方面。尽管我们在健康和疾病中的人类蛋白质组学知识方面已经取得了一些进展，但迫切需要制定一个具有明确里程碑的连贯路线图来指导蛋白质组学工作。重点领域包括：（1）构建资源，（2）填补我们对生物变异理解的空白，以及（3）系统地描述在明确界定的疾病状态中发生的蛋白质组变化，所有这些都需要有组织的协作努力。
