Center for Studies on Human Stress, Fernand-Seguin Research Center, Louis-H. Lafontaine Hospital, Canada.
Neurobiol Learn Mem. 2011 Nov;96(4):583-95. doi: 10.1016/j.nlm.2011.02.016. Epub 2011 Mar 2.
This review aims to discuss the evidence supporting the link between chronic stress, cognitive function and mental health. Over the years, the associations between these concepts have been investigated in different populations. This review summarizes the findings that have emerged from older populations as well as from populations suffering from pathological aging, namely Mild Cognitive Impairment and Alzheimer's Disease. Although older adults are an interesting population to study in terms of chronic stress, other stress-related diseases can occur throughout the lifespan. The second section covers some of these stress-related diseases that have recently received a great deal of attention, namely burnout, depression, and post-traumatic stress disorder. Given that chronic stress contributes to the development of certain pathologies by accelerating and/or exacerbating pre-existing vulnerabilities that vary from one individual to the other, the final section summarizes data obtained on potential variables contributing to the association between chronic stress and cognition.
本综述旨在讨论慢性应激、认知功能和心理健康之间关联的证据。多年来，不同人群一直在研究这些概念之间的关联。本综述总结了来自老年人群体以及患有病理性衰老的人群（即轻度认知障碍和阿尔茨海默病）的研究结果。虽然老年人是研究慢性应激的一个有趣群体，但其他与应激相关的疾病可能会在整个生命周期中发生。第二部分涵盖了一些最近受到广泛关注的与应激相关的疾病，即倦怠、抑郁和创伤后应激障碍。鉴于慢性应激通过加速和/或加剧个体之间存在的不同的、预先存在的脆弱性，从而导致某些病理的发展，最后一部分总结了关于可能导致慢性应激与认知之间关联的潜在变量的数据。
