Altman R D
Division of Rheumatology, School of Medicine, University of Miami, Florida 33101.
Scand J Rheumatol Suppl. 1990;81:24-7. doi: 10.3109/03009749009096942.
Clinical features of osteoarthritis (OA) require that general recommendations for the design and conduct of clinical trials be modified in order to apply these concepts to clinical trials in OA. A format has been devised for design of clinical trials in OA. In order to assess the applicability of this format, it has been compared to a published clinical trial: chondroprotective agents versus standard treatment of OA of the knee. The published study appeared reliably designed and conducted in a manner that provided an answer to most of the questions posed. The study appears to form a sound basis for additional studies.
