Rejholec V
Policlinic of the Medical Faculty, Charles University, Prague, Czechoslovakia.
Scand J Rheumatol Suppl. 1990;81:28-31. doi: 10.3109/03009749009096943.
Two long-term studies of chondroprotective agents in the treatment of osteoarthritis (OA) have been the subject of considerable interest. The studies included large numbers of patients with OA of the hip and of the knee followed for ten and five years. A range of criteria were chosen as parameters for monitoring the progression of disease, and statistical analysis of the results showed that GP-C modified positively the progression of OA. In view of the large number of criteria assessed, and the complexity of the results, it was decided that a reevaluation of the gonarthritis study would be appropriate using a range of indices in the statistical analysis. The statistical re-analysis of data confirmed that long-term treatment with GP-C positively modifies the progression of OA.
两项关于软骨保护剂治疗骨关节炎（OA）的长期研究备受关注。这些研究纳入了大量髋部和膝部骨关节炎患者，随访时间分别为十年和五年。选择了一系列标准作为监测疾病进展的参数，结果的统计分析表明，GP-C对骨关节炎的进展有积极的改善作用。鉴于评估的标准众多且结果复杂，决定使用一系列指标进行统计分析，对膝关节炎研究进行重新评估是合适的。对数据的统计重新分析证实，长期使用GP-C治疗可积极改善骨关节炎的进展。
