Moskowitz R W
Division of Rheumatic Diseases, Case Western Reserve University, Ohio 44106.
Scand J Rheumatol Suppl. 1990;81:21-3. doi: 10.3109/03009749009096941.
Studies of osteoarthritis (OA) in humans are restricted by the slow rate at which the disease progresses, and the limited opportunity for study of the tissue changes over time. A range of animal models of OA have been developed which demonstrate histopathological and gross features typical of OA in humans. Animal models can be used to study OA, and to investigate the effects of a variety of agents, including so-called chondroprotective agents, on the progression of the disease.
人类骨关节炎（OA）的研究受到疾病进展缓慢以及随时间研究组织变化机会有限的限制。已经开发出一系列OA动物模型，这些模型展现出人类OA典型的组织病理学和大体特征。动物模型可用于研究OA，并调查包括所谓软骨保护剂在内的多种药物对疾病进展的影响。
