Erciyes University, Faculty of Medicine, Department of Radiology, Kayseri, Turkey.
Eur J Radiol. 2011 Aug;79(2):e33-7. doi: 10.1016/j.ejrad.2010.12.089. Epub 2011 Mar 3.
The aim of our study was to investigate the value of choline in the discrimination of benign and malignant soft tissue and bone tumors.
The study group consisted of thirty subjects with bone or soft tissue tumors larger than 1.5 cm in diameter. The experiments were performed in a 1.5T MR scanner. Coils were selected according to specific locations. A single-voxel MRS was performed for three different TE (time to echo) (31, 136, 272 ms). The volume of interest was positioned on the brightest enhancement. The presence of a cholin peak on at least 2 of these spectrums was considered as the marker of malignancy. The sensitivity, specificity and accuracy of the MRS in the detection and diagnosis of malignant lesions were calculated. The reproducibility of MRS and histopathological results were tested with kappa statistics.
Histopathologically, 18 (60%) of the lesions were classed as malignant whereas 12 (40%) were classed as benign. With MRS, 15 (50%) of these lesions were classed as malignant and 15 (50%) as benign. Two patients who were found spectroscopically to have malignant tumors were shown histopathologically to have benign types. Five patients with an MRS showing a benign type were classed with malignant types in histopathological examinations. MRS had a sensitivity rate of 72.2%, specificity of 83.3%, and an accuracy rate of 76.6% in detecting malignant bone and soft tissue tumors. The interrater reliability of both techniques had a kappa value of 0.533.
MRS may help in the differentiation of benign and malignant soft tissue and bone tumors.
我们研究的目的是探讨胆碱在鉴别良恶性软组织和骨肿瘤中的价值。
研究组包括 30 名直径大于 1.5cm 的骨或软组织肿瘤患者。实验在 1.5TMR 扫描仪上进行。根据特定部位选择线圈。对三个不同的 TE（回波时间）（31、136、272ms）进行单体素 MRS。感兴趣区位于最亮增强区。如果在至少 2 个光谱上存在胆碱峰，则认为是恶性的标志物。计算 MRS 对恶性病变的检测和诊断的敏感性、特异性和准确性。用 Kappa 统计检验 MRS 和组织病理学结果的可重复性。
组织病理学上，18 个（60%）病变被归类为恶性，12 个（40%）为良性。MRS 检查显示，15 个（50%）病变为恶性，15 个（50%）为良性。2 名光谱检查发现为恶性肿瘤的患者，组织病理学检查结果为良性。5 名 MRS 显示良性类型的患者，组织病理学检查结果为恶性类型。MRS 检测良恶性骨软组织肿瘤的敏感性为 72.2%，特异性为 83.3%，准确性为 76.6%。两种技术的组内可靠性的 Kappa 值为 0.533。
MRS 可能有助于鉴别良恶性软组织和骨肿瘤。
