Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
Curr Biol. 2011 Mar 22;21(6):480-4. doi: 10.1016/j.cub.2011.01.069. Epub 2011 Mar 3.
GABA modification plays an important role in motor cortical plasticity. We therefore hypothesized that interindividual variation in the responsiveness of the GABA system to modification influences learning capacity in healthy adults. We assessed GABA responsiveness by transcranial direct current stimulation (tDCS), an intervention known to decrease GABA. The magnitude of M1 GABA decrease induced by anodal tDCS correlated positively with both the degree of motor learning and the degree of fMRI signal change within the left M1 during learning. This study therefore suggests that the responsiveness of the GABAergic system to modification may be relevant to short-term motor learning behavior and learning-related brain activity.
GABA 修饰在运动皮层可塑性中起着重要作用。因此，我们假设 GABA 系统对修饰的反应性的个体间差异会影响健康成年人的学习能力。我们通过经颅直流电刺激（tDCS）来评估 GABA 的反应性，tDCS 是一种已知可以降低 GABA 的干预措施。阳极 tDCS 诱导的 M1 GABA 减少幅度与运动学习的程度以及学习过程中左 M1 内 fMRI 信号变化的程度呈正相关。因此，这项研究表明，GABA 能系统对修饰的反应性可能与短期运动学习行为和与学习相关的大脑活动有关。
