杜氏利什曼原虫前鞭毛体膜中依赖流动性的Mg2(+)-ATP酶活性
Fluidity-dependent Mg2(+)-ATPase activity in membranes from Leishmania donovani promastigotes.
作者信息
Dutta M, Bandyopadhyay R, Ghosh C, Basu M K
机构信息
Biomembrane Division, Indian Institute of Chemical Biology, Calcutta.
出版信息
Biochem J. 1990 Feb 1;265(3):923-6. doi: 10.1042/bj2650923.
Abstract
The state of the lipid phase of the membrane plays a key role in the exposure of various receptors, antigens and enzymes on the membrane surface. The fluidity of membranes of Leishmania donovani promastigotes was monitored by two independent methods, i.e. influx of sterol from liposomes and removal of phospholipids by treatment with phospholipase C. The altered sterol/phospholipid ratio, in both cases, provided evidence that the activity of the functionally important membrane-bound enzyme Mg2(+)-ATPase is modulated by the state of the lipid phase of the membrane.
摘要
膜脂相的状态在各种受体、抗原和酶在膜表面的暴露中起关键作用。通过两种独立的方法监测杜氏利什曼原虫前鞭毛体膜的流动性，即甾醇从脂质体的流入和用磷脂酶C处理去除磷脂。在这两种情况下，甾醇/磷脂比的改变都提供了证据，表明功能重要的膜结合酶Mg2(+)-ATP酶的活性受膜脂相状态的调节。
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