Goad L J, Holz G G, Beach D H
Mol Biochem Parasitol. 1984 Feb;10(2):161-70. doi: 10.1016/0166-6851(84)90004-5.
The major sterol of promastigotes of stocks of Leishmania tropica, L. donovani and 3 subspecies of L. mexicana has been identified as ergosta-5,7,24(28)-trien-3 beta-ol; and of an L. major stock as ergosta-7,24(28)-dien-3 beta-ol. 24-Methylcholesta-5,7,22-trien-3 beta-ol and 24-ethylcholesta-5,7,22-trien-3 beta-ol were minor constituents, and traces of ergosta-5,7,22,24(28)-tetraen-3 beta-ol and a C27-diene were also recognized in some species. Lanosterol and 4,4-dimethylcholesta-8,24-dien-3 beta-ol were detected in all species studied, and squalene was identified in a stock of L. tropica. The sterol composition of members of the genus Leishmania and the sterol biosynthetic pathways it implies are characteristic of yeast and other fungi.
热带利什曼原虫、杜氏利什曼原虫及墨西哥利什曼原虫3个亚种前鞭毛体的主要固醇已被鉴定为麦角甾-5,7,24(28)-三烯-3β-醇；一株硕大利什曼原虫的主要固醇为麦角甾-7,24(28)-二烯-3β-醇。24-甲基胆甾-5,7,22-三烯-3β-醇和24-乙基胆甾-5,7,22-三烯-3β-醇为次要成分，在某些物种中还检测到微量的麦角甾-5,7,22,24(28)-四烯-3β-醇和一种C27-二烯。在所研究的所有物种中均检测到羊毛甾醇和4,4-二甲基胆甾-8,24-二烯-3β-醇，在一株热带利什曼原虫中鉴定出了角鲨烯。利什曼原虫属各成员的固醇组成及其所暗示的固醇生物合成途径是酵母和其他真菌所特有的。
