Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 210093 Nanjing, China.
Talanta. 2011 Apr 15;84(2):293-7. doi: 10.1016/j.talanta.2011.01.017. Epub 2011 Jan 15.
Unit operations for complicated biochemical analysis cannot usually be integrated into one substrate. A possible solution to solve this problem is to integrate multi-unit operations into two or more substrates. In this case, transporting droplets from one substrate to another is essential. In this work, a new method to transport droplets from a hydrophobic glass substrate to a piezoelectric substrate is proposed. An interdigitated transducer (IDT) and reflectors were fabricated on an optic grade 128°YX-cut lithium niobate (LiNbO(3)) substrate, and its working surface between the IDT and a reflector was modified to be hydrophobic. Droplets to be transported were first pipetted onto a glass substrate. Adjust the glass substrate so that the droplets could contact the working surface of the piezoelectric substrate, and then was moved down. These droplets could be successfully transported from the glass surface to the piezoelectric substrate because of their "adhesion work" difference. By using this mechanism, water and red dye droplets were successfully transported from glass substrate to piezoelectric substrate. As an application, droplets mixing process was demonstrated in the piezoelectric substrate by using surface acoustic wave after they have been transported from the glass substrate.
复杂生化分析的单元操作通常无法集成到一个基底上。解决这个问题的一种可能方法是将多个单元操作集成到两个或更多的基底上。在这种情况下，将液滴从一个基底传输到另一个基底是至关重要的。在这项工作中，提出了一种将液滴从疏水玻璃基底传输到压电基底的新方法。在光学级 128°YX 切铌酸锂（LiNbO(3)）基底上制造了叉指换能器（IDT）和反射器，并且其在 IDT 和反射器之间的工作表面被修改为疏水。要传输的液滴首先被吸到玻璃基底上。调整玻璃基底，使液滴能够接触压电基底的工作表面，然后向下移动。由于“粘附功”的差异，这些液滴可以成功地从玻璃表面传输到压电基底上。通过使用这种机制，成功地将水和红色染料液滴从玻璃基底传输到压电基底上。作为一种应用，在将液滴从玻璃基底传输到压电基底之后，通过表面声波在压电基底中演示了液滴混合过程。
