Bird M, Kornetsky C
Laboratory of Behavioral Pharmacology, Boston University School of Medicine, MA 02118.
Neuropsychopharmacology. 1990 Feb;3(1):33-40.
The decreased sensitivity of animals to rewarding brain stimulation caused by pimozide has been interpreted as a selective pharmacologic blockade of central reward pathways rather than a nonspecific disruption of performance. In an attempt to confirm this hypothesis, the effects of pimozide on both reward and detection thresholds for intracranial stimulation delivered to the medial forebrain bundle-lateral hypothalamic area (MFB-LH) were determined in four animals. The drug caused a systematic increase in the reward threshold of each subject but had no such effect on the detection threshold. We conclude that pimozide selectively inhibits the rewarding effects of brain stimulation, and that therefore, the D2 dopamine receptor has a major role in activating central reward pathways subserving pharmacologic and electrical reinforcement. The dual anhedonic/antipsychotic effects of neuroleptic medication are discussed as a possible paradox of central importance to the psychopathology of schizophrenia.
匹莫齐特导致动物对脑奖赏性刺激的敏感性降低，这被解释为对中枢奖赏通路的选择性药理阻断，而非对行为表现的非特异性破坏。为了证实这一假说，在四只动物身上测定了匹莫齐特对传递至内侧前脑束-外侧下丘脑区域（MFB-LH）的颅内刺激的奖赏阈值和检测阈值的影响。该药物使每个实验对象的奖赏阈值系统性升高，但对检测阈值没有此类影响。我们得出结论，匹莫齐特选择性抑制脑刺激的奖赏效应，因此，D2多巴胺受体在激活介导药理和电强化的中枢奖赏通路中起主要作用。抗精神病药物的双重快感缺失/抗精神病效应被作为对精神分裂症精神病理学可能具有核心重要性的一个悖论进行了讨论。
