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Isolation of a novel bacteriophage specific for the periodontal pathogen Fusobacterium nucleatum.分离一种新型噬菌体，特异性针对牙周病原菌核梭杆菌。
Appl Environ Microbiol. 2010 Nov;76(21):7243-50. doi: 10.1128/AEM.01135-10. Epub 2010 Sep 17.
2
Characterization of a new serotype g isolate of Aggregatibacter actinomycetemcomitans.一株新血清型 g 分离株伴放线放线杆菌的特性研究。
Mol Oral Microbiol. 2010 Jun;25(3):200-6. doi: 10.1111/j.2041-1014.2010.00572.x.
3
Genetic diversity and toxic activity of Aggregatibacter actinomycetemcomitans isolates.伴放线聚集杆菌分离株的遗传多样性和毒性活性
Oral Microbiol Immunol. 2009 Dec;24(6):493-501. doi: 10.1111/j.1399-302X.2009.00547.x.
4
Novel anti-microbial therapies for dental plaque-related diseases.用于治疗牙菌斑相关疾病的新型抗菌疗法。
Int J Antimicrob Agents. 2009 Jan;33(1):8-13. doi: 10.1016/j.ijantimicag.2008.07.014. Epub 2008 Sep 18.
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Prevalence and distribution of principal periodontal pathogens worldwide.全球主要牙周病原体的患病率及分布情况。
J Clin Periodontol. 2008 Sep;35(8 Suppl):346-61. doi: 10.1111/j.1600-051X.2008.01280.x.
6
Periodontal diseases and health: Consensus Report of the Sixth European Workshop on Periodontology.牙周疾病与健康：第六届欧洲牙周病学研讨会共识报告
J Clin Periodontol. 2008 Sep;35(8 Suppl):333-7. doi: 10.1111/j.1600-051X.2008.01278.x.
7
Screen for leukotoxin mutants in Aggregatibacter actinomycetemcomitans: genes of the phosphotransferase system are required for leukotoxin biosynthesis.牙龈卟啉单胞菌中白细胞毒素突变体的筛选：磷酸转移酶系统的基因是白细胞毒素生物合成所必需的。
Infect Immun. 2008 Aug;76(8):3561-8. doi: 10.1128/IAI.01687-07. Epub 2008 Jun 9.
8
Aggregatibacter actinomycetemcomitans and its relationship to initiation of localized aggressive periodontitis: longitudinal cohort study of initially healthy adolescents.伴放线聚集杆菌及其与局限性侵袭性牙周炎发病的关系：对最初健康的青少年进行的纵向队列研究
J Clin Microbiol. 2007 Dec;45(12):3859-69. doi: 10.1128/JCM.00653-07. Epub 2007 Oct 17.
9
Antibiotic resistance in an in vitro subgingival biofilm model.体外龈下生物膜模型中的抗生素耐药性
Oral Microbiol Immunol. 2007 Oct;22(5):333-9. doi: 10.1111/j.1399-302X.2007.00366.x.
10
Systemic antibiotic therapy in the treatment of periodontitis.全身用抗生素治疗牙周炎。
J Can Dent Assoc. 2007 Jul-Aug;73(6):515-20.

分离一种新型伴放线放线杆菌 b 型噬菌体能在生物膜内裂解细菌。

Isolation of a novel Aggregatibacter actinomycetemcomitans serotype b bacteriophage capable of lysing bacteria within a biofilm.

机构信息

Laboratorio de Microbiología y Biotecnología Oral, Universidad Andres Bello, Echaurren 237, Santiago, Chile.

出版信息

Appl Environ Microbiol. 2011 May;77(9):3157-9. doi: 10.1128/AEM.02115-10. Epub 2011 Mar 4.

DOI:10.1128/AEM.02115-10
PMID:21378052
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3126385/
Abstract

A bacteriophage specific for Aggregatibacter actinomycetemcomitans serotype b, able to kill the bacterium within a biofilm, was isolated. Random mutagenesis of this phage rendered a bacteriophage able to kill 99% of the bacteria within a biofilm. This is the first report of a biocontrol experiment against A. actinomycetemcomitans.

摘要

分离到一株能特异性裂解伴放线放线杆菌 b 型的噬菌体，该噬菌体能在生物膜内杀死细菌。该噬菌体经随机突变后，能杀死生物膜内 99%的细菌。这是首次报道针对伴放线放线杆菌的生物防治实验。