Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou 510180, China.
Department of Endoscopy, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou 510091, China.
Int J Clin Pract. 2022 Oct 3;2022:4913146. doi: 10.1155/2022/4913146. eCollection 2022.
Intestinal microbiota plays a key role in regulating the pathogenesis of human disease and maintaining health. Many diseases, mainly induced by bacteria, are on the rise due to the emergence of antibiotic-resistant strains. Intestinal microorganisms include organisms such as bacteria, viruses, and fungi. They play an important role in maintaining human health. Among these microorganisms, phages are the main members of intestinal viromes. In particular, the viral fraction, composed essentially of phages, affects homeostasis by exerting selective pressure on bacterial communities living in the intestinal tract. In recent years, with the widespread use and even abuse of antibacterial drugs, more and more drug-resistant bacteria have been found, and they show a trend of high drug resistance and multidrug resistance. Therefore, it has also become increasingly difficult to treat serious bacterial infections. Phages, a natural antibacterial agent with strong specificity and rapid proliferation, have come back to the field of vision of clinicians and scholars. In this study, the current state of research on intestinal phages was discussed, with an exploration of the impact of phage therapy against infectious diseases, as well as potential application beyond infectious diseases.
肠道微生物在调节人类疾病的发病机制和维持健康方面发挥着关键作用。由于抗生素耐药菌株的出现，许多主要由细菌引起的疾病正在呈上升趋势。肠道微生物包括细菌、病毒和真菌等生物体。它们在维持人类健康方面发挥着重要作用。在这些微生物中，噬菌体是肠道病毒组的主要成员。特别是由噬菌体组成的病毒部分通过对生活在肠道中的细菌群落施加选择性压力来影响内稳态。近年来，随着抗菌药物的广泛应用甚至滥用，越来越多的耐药菌被发现，且它们表现出高耐药性和多药耐药性的趋势。因此，治疗严重细菌感染也变得越来越困难。噬菌体作为一种具有强特异性和快速增殖能力的天然抗菌剂，重新回到了临床医生和学者的视野。本研究探讨了肠道噬菌体的研究现状，探索了噬菌体治疗对抗感染性疾病的影响，以及超越感染性疾病的潜在应用。
