Vacheron F, Rudent A, Perin S, Labarre C, Quero A M, Guenounou M
Laboratoire de Microbiologie, UFR de Médecine Paris-Ouest, Hôpital Raymond-Poincare, Garches, France.
J Gen Virol. 1990 Feb;71 ( Pt 2):477-9. doi: 10.1099/0022-1317-71-2-477.
Mice were infected with influenza A virus by aerosol. Bronchoalveolar washings obtained from infected mice contained interleukin 1 (IL-1) and tumour necrosis factor (TNF) activities. IL-1 was present at day 4 post-infection but not at day 7. TNF activity was present at day 4 and day 7 post-infection. The presence of both these monokines was coincident with increased cell populations in the lungs. In vitro studies demonstrated that macrophages from non-infected mice produce IL-1 and TNF activities in response to live influenza A virus stimulation. These results suggest that a direct interaction between virus and alveolar macrophages leads to IL-1 and TNF production during the course of infection and could account for both the immune responses and the pathology that occur during influenza A virus infection.
通过气溶胶将甲型流感病毒感染小鼠。从受感染小鼠获得的支气管肺泡灌洗液含有白细胞介素1（IL-1）和肿瘤坏死因子（TNF）活性。IL-1在感染后第4天存在，但在第7天不存在。TNF活性在感染后第4天和第7天存在。这两种单核因子的存在与肺中细胞数量增加一致。体外研究表明，来自未感染小鼠的巨噬细胞在活甲型流感病毒刺激下产生IL-1和TNF活性。这些结果表明，病毒与肺泡巨噬细胞之间的直接相互作用导致感染过程中IL-1和TNF的产生，并且可以解释甲型流感病毒感染期间发生的免疫反应和病理情况。
