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Pharmacol Biochem Behav. 1978 Aug;9(2):161-6. doi: 10.1016/0091-3057(78)90159-4.
The habituation of an orienting response to auditory stimuli was impaired in rats by the administration of ACTH1-24. This impairment is unlikely to be due to the action of corticosterone because of the time course of the effect, because injected corticosterone had no effect on hibituation and because the peptide fragment ACTH4-10, which does not release corticosterone, also impaired habituation. Both ACTH1-24 and ACTH4-10 reduced the level of exploration measured in a holeboard, but corticosterone had no significant effect. However ACTH did not impair habituation and exploration, thus providing further evidence that there are different mechanisms underlying habituation of orienting and habituation of exploration.
给大鼠注射促肾上腺皮质激素1 - 24（ACTH1 - 24）会损害其对听觉刺激的定向反应习惯化。由于这种效应的时间进程，这种损害不太可能是由于皮质酮的作用，因为注射皮质酮对习惯化没有影响，而且不释放皮质酮的肽片段促肾上腺皮质激素4 - 10（ACTH4 - 10）也会损害习惯化。ACTH1 - 24和ACTH4 - 10都降低了在洞板实验中测量的探索水平，但皮质酮没有显著影响。然而，促肾上腺皮质激素不会损害习惯化和探索，从而进一步证明了定向习惯化和探索习惯化背后存在不同的机制。
