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Pharmacol Biochem Behav. 1976 Jun;4(6):695-702. doi: 10.1016/0091-3057(76)90222-7.
Experiment 1 tested the generality of Carlton's hypothesis that central muscarinic cholinergic pathways are involved in habituation of exploration. The effects of 3 muscarinic antagonists were tested in a holeboard, under 2 test conditions, i.e. with objects absent or present. Both the frequency and the duration of head-dipping were used as measures of exploration. Scopolamine prevented habituation only of the frequency of head-dipping, and only when objects were present. Atropine and benzhexol did not impair the habituation of either frequency of duration of head-dipping in either test condition. The impairment of habituation seemed therefore to be specific to scopolamine, and to the more complex test condition, and thus there was little to justify the suggestion that central cholinergic paths were generally involved. Experiment 2 investigated the effects of muscarinic antagonists on habituation of distraction. None of the drugs affected the distraction to tones, nor the subsequent habituation to these stimuli. Central cholinergic paths do not therefore seem to be involved in habituation of this behavioral response.
实验1检验了卡尔顿的假设的普遍性，即中枢毒蕈碱能胆碱能通路参与探索行为的习惯化。在一个洞板中，在两种测试条件下，即物体不存在或存在的情况下，测试了3种毒蕈碱拮抗剂的作用。头部探入的频率和持续时间都被用作探索行为的测量指标。东莨菪碱仅在物体存在时阻止了头部探入频率的习惯化。在两种测试条件下，阿托品和苯海索均未损害头部探入频率或持续时间的习惯化。因此，习惯化的损害似乎是东莨菪碱特有的，并且是针对更复杂的测试条件，因此几乎没有理由表明中枢胆碱能通路普遍参与其中。实验2研究了毒蕈碱拮抗剂对分心习惯化的影响。这些药物均未影响对音调的分心，也未影响随后对这些刺激的习惯化。因此，中枢胆碱能通路似乎不参与这种行为反应的习惯化。
