Microbial Diseases, UCL Eastman Dental Institute, University College London, London, UK.
Photochem Photobiol Sci. 2011 May;10(5):712-20. doi: 10.1039/c0pp00360c. Epub 2011 Mar 7.
Photodynamic therapy (PDT) has been proposed as a new technique to inactivate microorganisms as it does not lead to the selection of mutant resistant strains; a clear benefit compared to antibiotic treatment. PDT has also attracted the interest of nanotechnology as the effectiveness of the treatment can be greatly enhanced by the use of nanoparticles. In the last decade, different approaches to the combination of nanoparticles and PDT have been investigated in relation to the antimicrobial applications of the technique. One use of the nanoparticles is to improve the delivery of photosensitiser to the bacteria; others use the nanoparticles to improve the inactivation kinetics. A different approach utilises nanoparticles as a photosensitiser. In this review these diverse types of interactions will be described.
光动力疗法（PDT）被提议作为一种新的技术来灭活微生物，因为它不会导致抗突变菌株的选择; 与抗生素治疗相比，这是一个明显的优势。PDT 也引起了纳米技术的兴趣，因为通过使用纳米粒子可以大大提高治疗的效果。在过去的十年中，已经研究了将纳米粒子与 PDT 相结合的不同方法，以研究该技术的抗菌应用。纳米粒子的一种用途是改善光敏剂向细菌的输送; 其他用途则利用纳米粒子来改善失活动力学。另一种方法是利用纳米粒子作为光敏剂。在这篇综述中，将描述这些不同类型的相互作用。
