流感病毒诱导的抑制细胞抑制小鼠白细胞介素-2的产生。
Suppressor cells induced by influenza virus inhibit interleukin-2 production in mice.
作者信息
Del Gobbo V, Villani N, Marini S, Balestra E, Caliò R
机构信息
Department of Experimental Medicine, II University of Rome, Italy.
出版信息
Immunology. 1990 Mar;69(3):454-9.
Abstract
PR8 virus depressed interleukin-2 (IL-2) and natural killer (NK) cell activity in BALB/c infected mice. IL-2 production was not dependent on (i) a decreased number of T cells or (ii) a primary defect in IL-1 production, but on a T-suppressor cell subpopulation. In fact, when T suppressor cells were removed from infected spleen cells, we observed normal levels of IL-2 activity.
摘要
PR8病毒会抑制感染BALB/c小鼠的白细胞介素-2（IL-2）和自然杀伤（NK）细胞活性。IL-2的产生并不依赖于（i）T细胞数量的减少或（ii）IL-1产生的原发性缺陷，而是依赖于一种T抑制细胞亚群。事实上，当从感染的脾细胞中去除T抑制细胞时，我们观察到IL-2活性处于正常水平。
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