Del Gobbo V, Villani N, Marini S, Balestra E, Caliò R
Department of Experimental Medicine, II University of Rome, Italy.
Immunology. 1990 Mar;69(3):454-9.
PR8 virus depressed interleukin-2 (IL-2) and natural killer (NK) cell activity in BALB/c infected mice. IL-2 production was not dependent on (i) a decreased number of T cells or (ii) a primary defect in IL-1 production, but on a T-suppressor cell subpopulation. In fact, when T suppressor cells were removed from infected spleen cells, we observed normal levels of IL-2 activity.
PR8病毒会抑制感染BALB/c小鼠的白细胞介素-2(IL-2)和自然杀伤(NK)细胞活性。IL-2的产生并不依赖于(i)T细胞数量的减少或(ii)IL-1产生的原发性缺陷,而是依赖于一种T抑制细胞亚群。事实上,当从感染的脾细胞中去除T抑制细胞时,我们观察到IL-2活性处于正常水平。