Casali P, Rice G P, Oldstone M B
J Exp Med. 1984 May 1;159(5):1322-37. doi: 10.1084/jem.159.5.1322.
We present experimental data that offer, in part, a better understanding of the immunosuppression that accompanies measles virus infection. We note that measles virus "silently" infects human lymphocytes and that the infection does not alter lymphocyte survival in vitro. Yet such infected lymphocytes fail to generate natural killer (NK) cell activity or synthesize immunoglobulins (Ig). Thus, the presence of virus within lymphocytes impairs their specific immune functions in the absence of cytolysis. Influenza virus also infects human lymphocytes. In contrast to measles virus infection of resting lymphocytes in which viral antigen is rarely expressed, influenza virus infection of these cells yields viral antigens expressed in the cytoplasm and on the cell surface. Influenza virus-infected lymphocytes have normal NK cell activity but fail to synthesize IgG or IgM.
我们提供的实验数据，部分有助于更好地理解麻疹病毒感染所伴随的免疫抑制情况。我们注意到，麻疹病毒“悄无声息地”感染人类淋巴细胞，且这种感染在体外不会改变淋巴细胞的存活情况。然而，这些被感染的淋巴细胞无法产生自然杀伤（NK）细胞活性，也不能合成免疫球蛋白（Ig）。因此，淋巴细胞内病毒的存在会在不发生细胞溶解的情况下损害其特异性免疫功能。流感病毒也会感染人类淋巴细胞。与麻疹病毒感染静息淋巴细胞时很少表达病毒抗原不同，流感病毒感染这些细胞会使病毒抗原在细胞质和细胞表面表达。感染流感病毒的淋巴细胞具有正常的NK细胞活性，但无法合成IgG或IgM。
