Otrashevskaia E V, Krasil'nikov I V, Ignat'ev G M
Vopr Virusol. 2010 Nov-Dec;55(6):15-9.
Postvaccination immunity was studied in the children and teenagers without a history of clinical mumps infection, who had been immunized with the Leningrad-3 mumps vaccine. The level of specific lgG in ELISA and that and spectrum of their neutralizing activity against a vaccine strain and three heterologous mumps virus (MV) strains (genotypes A, C, and H) were measured. The investigation included 151 sera from the vaccinees aged 3 to 17 years, possessing the detectable specific IgG titers in ELISA and the detectable neutralizing titers against the vaccine strain. 97.4% of the vaccinees had neutralizing activity against 1-3 heterologous MV strains. A preponderance of neutralizing titers against heterologous MV strains by 1-log2 in some sera (6.5-32.5 depending on age) was most likely to suggest that the vaccinees' had been in contact with these virus strains in the past. In our investigation, a combination of positive IgG titers and neutralizing titers against the vaccine strain 2-log2 or higher provided the protection of the vaccinated children and teenagers against the symptomatic infection. There was a pronounced buster effect of the second immunization and a drop in the neutralizing activity of the sera from the vaccinated children and adolescents over time after the first and second immunization.
对未曾有过临床腮腺炎感染史、接种过列宁格勒-3腮腺炎疫苗的儿童和青少年进行了接种后免疫研究。检测了酶联免疫吸附测定（ELISA）中特异性IgG的水平及其针对疫苗株和三种异源腮腺炎病毒（MV）株（A、C和H基因型）的中和活性谱。该研究纳入了151份来自3至17岁接种者的血清，这些血清在ELISA中具有可检测到的特异性IgG滴度以及针对疫苗株的可检测到的中和滴度。97.4%的接种者对1至3种异源MV株具有中和活性。在一些血清中（根据年龄不同，中和滴度比异源MV株高1-log2，即6.5-32.5），这很可能表明接种者过去曾接触过这些病毒株。在我们的研究中，针对疫苗株的IgG滴度和中和滴度呈阳性且达到2-log2或更高，可为接种疫苗的儿童和青少年提供针对有症状感染的保护。第二次免疫有明显的增强效应，并且在第一次和第二次免疫后，接种疫苗的儿童和青少年血清的中和活性随时间下降。
