[慢性病毒性肝炎患者的生活质量指标]

[Quality of life indices in patients with chronic viral hepatitis].

作者信息

Beloborodova E I, Lambrova E G, Beloborodova E V, Ostanko V L, Alekseeva A S, Kalacheva T P, Livshits I K, Chvyrina D V

出版信息

Ter Arkh. 2010;82(11):41-5.

Abstract

AIM

to estimate quality of life (QL) indices in patients with chronic viral hepatitis (CVH) and their relationships to the clinical characteristics of the disease.

SUBJECTS AND METHODS

One hundred and ten patients with chronic viral hepatitis (CVH), including 58 patients with chronic hepatitis C (CHC), 27 with chronic hepatitis B, and 25 with CHC + HBCor, were examined. The personality psychological profile, reaction and personality anxiety were evaluated; the Beck inventory was used to identify borderline mental disorders. The test developed by the Karelian Research Center, Russian Academy of Medical Sciences, modified by Ya. M. Rutgaizer, and the Nottingham Health Profile were applied to estimate QL indices.

RESULTS

Parameters characterizing the social and personality indices of life, such as qualitative performance of paid work, participation in social life, impossibility of adequate rest, and sexual life are most frequently influenced. The main indicators of worse QL were diminished vitality (vital energy), sleep disorders, and emergence of emotional reactions. This was largely seen in patients with active CVH infection and in those who had isolated HBcor antibodies.

CONCLUSION

QL is directly related to the duration of viral infection.

摘要

目的

评估慢性病毒性肝炎（CVH）患者的生活质量（QL）指标及其与疾病临床特征的关系。

对象与方法

对110例慢性病毒性肝炎（CVH）患者进行检查，其中包括58例慢性丙型肝炎（CHC）患者、27例慢性乙型肝炎患者和25例慢性丙型肝炎合并乙肝核心抗体（CHC + HBCor）患者。评估患者的个性心理特征、反应和个性焦虑；使用贝克量表确定边缘性精神障碍。应用俄罗斯医学科学院卡累利阿研究中心开发并经雅·M·鲁特盖泽修改的测试以及诺丁汉健康量表来评估QL指标。