Sansom Institute for Health Research, University of South Australia, Frome Road, Adelaide, 5000, South Australia.
J Nat Prod. 2011 Apr 25;74(4):650-7. doi: 10.1021/np100701s. Epub 2011 Mar 7.
Four new benzoyl ester clerodane diterpenoids, 15,16-epoxy-8α-(benzoyloxy)methylcleroda-3,13(16),14-trien-18-oic acid (1), 15,16-epoxy-8α-(benzoyloxy)methyl-2α-hydroxycleroda-3,13(16),14-trien-18-oic acid (2), 15,16-epoxy-8α-(benzoyloxy)methyl-2-oxocleroda-3,13(16),14-trien-18-oic acid (3), and 15,16-epoxy-2α-benzoyloxycleroda-3,13(16),14-trien-18-oic acid (4), have been isolated from the leaves and stems of Dodonaea polyandra. The anti-inflammatory activities of compounds 1, 2, and 4 were evaluated by means of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema. Compounds 2 and 4 exhibited maximum inhibition of inflammation (70-76%) at doses of 0.22 and 0.9 μmol/ear, respectively. Modest activity (~45% inhibition) was maintained at nanomole/ear doses.
从 Dodonaea polyandra 的叶和茎中分离得到了四个新的苯甲酰酯 clerodane 二萜类化合物，分别为 15,16-环氧-8α-(苯甲酰氧基)甲基 cleroda-3,13(16),14-三烯-18-酸（1）、15,16-环氧-8α-(苯甲酰氧基)甲基-2α-羟基 cleroda-3,13(16),14-三烯-18-酸（2）、15,16-环氧-8α-(苯甲酰氧基)甲基-2-氧代 cleroda-3,13(16),14-三烯-18-酸（3）和 15,16-环氧-2α-苯甲酰氧基 cleroda-3,13(16),14-三烯-18-酸（4）。化合物 1、2 和 4 通过 12-O-十四烷酰佛波醇-13-醋酸酯（TPA）诱导的小鼠耳肿胀实验评估了抗炎活性。化合物 2 和 4 在 0.22 和 0.9 μmol/耳剂量下表现出最大的抗炎抑制作用（70-76%）。在纳摩尔/耳剂量下仍保持适度的活性（~45%抑制）。
