Aminimoghadamfarouj Noushin, Nematollahi Alireza
Faculty of Pharmacy A15, The University of Sydney, Sydney NSW 2006, Australia.
Int J Mol Sci. 2017 Jun 17;18(6):1290. doi: 10.3390/ijms18061290.
Propolis is one of the complex, but valuable, bio-sources for discovering therapeutic compounds. Diterpenes are organic compounds composed of four isoprene units and are known for their biological and pharmacological characteristics, such as antibacterial, anticancer, and anti-inflammatory activities. Recently, advancements have been made in the development of antibacterial and anticancer leads from propolis-isolated diterpenes, and scrutiny of these compounds is being pursued. Thus, this review covers the progress in this arena, with a focus on the chemistry and biological activities of propolis diterpenes. It is anticipated that important information, in a comprehensive and concise manner, will be delivered here for better understanding of natural product drug discovery research.
蜂胶是发现治疗性化合物的复杂但有价值的生物来源之一。二萜是由四个异戊二烯单元组成的有机化合物，以其生物和药理特性而闻名，如抗菌、抗癌和抗炎活性。最近，从蜂胶分离的二萜类化合物在抗菌和抗癌先导化合物的开发方面取得了进展，并且正在对这些化合物进行详细研究。因此，本综述涵盖了这一领域的进展，重点是蜂胶二萜的化学和生物活性。预计将以全面和简洁的方式提供重要信息，以便更好地理解天然产物药物发现研究。
