关于 2-羟乙基膦酸双加氧酶的立体化学。
On the stereochemistry of 2-hydroxyethylphosphonate dioxygenase.
机构信息
Howard Hughes Medical Institute and Roger Adams Laboratory, Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA.
出版信息
J Am Chem Soc. 2011 Mar 30;133(12):4236-9. doi: 10.1021/ja1113326. Epub 2011 Mar 7.
Abstract
Stereochemical investigations have shown that the conversion of 2-hydroxyethylphosphonate to hydroxymethylphosphonate by the enzyme HEPD involves removal of the pro-S hydrogen at C2 and, surprisingly, the loss of stereochemical information at C1. As a result, the mechanisms previously proposed for HEPD must be re-evaluated.
摘要
立体化学研究表明，酶 HEPD 将 2-羟乙基膦酸转化为羟甲基膦酸涉及 C2 上的 Pro-S 氢的去除，令人惊讶的是，C1 处的立体化学信息丢失。因此，先前提出的 HEPD 机制必须重新评估。
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