Department of Neurology, 2 Gibson, Hospital of the University of Pennsylvania, 3400 Spruce St., Philadelphia, PA 19104-4283, USA.
Neuropsychology. 2011 Mar;25(2):159-65. doi: 10.1037/a0021448.
Patients with Corticobasal Syndrome (CBS) have atrophy in posterior parietal cortex. This region of atrophy has been previously linked with quantifier comprehension difficulty, but previous studies employed visual stimuli, making it difficult to account for potentially confounding visuospatial deficits in CBS patients. The current study evaluated comprehension of generalized quantifiers using strictly verbal materials.
Non-aphasic CBS patients, a brain-damaged control group (consisting of patients with Alzheimer's disease and frontotemporal dementia), and age-matched healthy controls participated in this study. We assessed familiar temporal, spatial, and monetary domains of verbal knowledge comparatively. Judgment accuracy was only evaluated in statements for which patients demonstrated accurate factual knowledge about the target domain.
We found that patients with CBS are significantly impaired in their ability to evaluate quantifiers when compared to healthy seniors and a brain-damaged control group, even in this strictly verbal task. This impairment was seen in the vast majority of individual CBS patients.
These findings offer additional evidence of quantifier impairment in CBS patients and emphasize that this impairment cannot be attributed to potential visuo spatial processing impairments in patients with parietal disease.
皮质基底节综合征（CBS）患者的后顶叶皮层有萎缩。该萎缩区域以前与量词理解困难有关，但以前的研究采用了视觉刺激，这使得难以解释 CBS 患者潜在的视觉空间缺陷。本研究使用严格的语言材料评估了广义量词的理解。
非失语性 CBS 患者、脑损伤对照组（包括阿尔茨海默病和额颞叶痴呆患者）和年龄匹配的健康对照组参与了这项研究。我们比较了熟悉的时间、空间和货币领域的语言知识。只有在患者对目标域有准确的事实知识的陈述中，才评估判断准确性。
我们发现，与健康老年人和脑损伤对照组相比，CBS 患者在评估量词的能力方面存在显著障碍，即使在这种严格的语言任务中也是如此。这一障碍在绝大多数个别 CBS 患者中都存在。
这些发现为 CBS 患者的量词障碍提供了额外的证据，并强调这种障碍不能归因于患有顶叶疾病的患者潜在的视觉空间处理障碍。
