Libon David J, Massimo Lauren, Moore Peachie, Coslett H Branch, Chatterjee Anjan, Aguirre Geoffrey K, Rice Aaron, Vesely Luisa, Grossman Murray
New Jersey Institute for Successful Aging, University of Medicine and Dentistry of New Jersey, School of Osteopathic Medicine, Stratford, NJ 08084, USA.
Dement Geriatr Cogn Disord. 2007;24(6):441-7. doi: 10.1159/000110577. Epub 2007 Oct 30.
A neuropsychological screening instrument sensitive to neuropsychological deficits associated with Alzheimer's disease (AD) and patients with frontotemporal dementia (FTD) would be valuable for diagnostic evaluation.
The Philadelphia Brief Assessment of Cognition (PBAC) assesses working memory/executive control, language, visuospatial operations, verbal/visual episodic memory, and behavior/social comportment and can be administered and scored in 15-20 min. Participants included 149 patients with AD and four groups of FTD patients - i.e., patients with a decline in social comportment, personality, and executive functioning (SOC/EXEC), semantic dementia (SemD), progressive nonfluent aphasia (PNFA), and corticobasal syndrome (CBS).
The total PBAC score correlated with the Mini-Mental State Examination. Between-group analysis of PBAC subscales and the results of logistic regression analyses produced substantial between-group differences, emphasizing the sensitivity of the test to differentiate dementia subtypes. AD patients were impaired on tests of episodic memory, SOC/EXEC patients were impaired on a measure of social comportment/behavioral disturbance, PNFA patients obtained low scores on tests of working memory/executive control, SemD patients obtained lower scores on language-mediated measures, and CBS patients were impaired on visuospatial/visual memory tests.
These data support the usefulness of the PBAC as a relatively brief screening test of overall dementia severity across a wide range of dementia patients.
一种对与阿尔茨海默病（AD）及额颞叶痴呆（FTD）患者相关的神经心理学缺陷敏感的神经心理学筛查工具，对于诊断评估具有重要价值。
费城简易认知评估（PBAC）评估工作记忆/执行控制、语言、视觉空间操作、言语/视觉情景记忆以及行为/社会行为表现，可在15至20分钟内完成施测与计分。参与者包括149例AD患者以及四组FTD患者，即社会行为表现、人格及执行功能下降的患者（SOC/EXEC）、语义性痴呆（SemD）、进行性非流畅性失语（PNFA）和皮质基底节综合征（CBS）患者。
PBAC总分与简易精神状态检查表相关。PBAC分量表的组间分析及逻辑回归分析结果显示出显著的组间差异，强调了该测试区分痴呆亚型的敏感性。AD患者在情景记忆测试中表现受损，SOC/EXEC患者在社会行为表现/行为障碍测量中表现受损，PNFA患者在工作记忆/执行控制测试中得分较低，SemD患者在语言介导测量中得分更低，CBS患者在视觉空间/视觉记忆测试中表现受损。
这些数据支持PBAC作为一种相对简短的筛查测试，可用于评估广泛的痴呆患者总体痴呆严重程度。
