Practice of Gastroenterology, Bergheimer Str. 56a, 69115 Heidelberg, Germany.
Expert Rev Med Devices. 2011 Mar;8(2):257-61. doi: 10.1586/erd.10.84.
Given the low compliance with screening colonoscopy in countries with a national colorectal cancer screening program, noninvasive methods with an acceptable high rate of sensitivity and specificity are welcome to enlarge the array of screening tools. Colon capsule endoscopy seems to be a safe and effective method of visualizing the colonic mucosa without the need for sedation or insufflation of air. Bowel cleansing for colon capsule endoscopy is more rigorous as only excellent or good results can be accepted in order to obtain an adequate sensitivity. This restricts its application on persons who are able to drink 4 l of polyethylene glycol plus laxatives. The sensitivity of colon capsule endoscopy to detect polyps, advanced adenomas and cancer is lower compared with optical colonoscopy. It still seems to be an adequate alternative for patients reluctant to undergo colonoscopy. Conventional colonoscopy is still established as the gold standard in colorectal cancer screening and is used to evaluate positive screening tests of all programs. It is the only method with the ability to remove detected polyps and obtain biopsy specimens.
鉴于在有国家结直肠癌筛查计划的国家中，筛查结肠镜检查的依从性较低，因此欢迎使用具有可接受的高灵敏度和特异性的非侵入性方法来扩大筛查工具的范围。结肠胶囊内镜似乎是一种安全有效的可视化结肠黏膜的方法，无需镇静或充气。结肠胶囊内镜的肠道清洁更为严格，因为只有获得极好或良好的结果才能被接受，以获得足够的灵敏度。这限制了其在能够饮用 4 升聚乙二醇加泻药的人群中的应用。与光学结肠镜相比，结肠胶囊内镜检测息肉、高级腺瘤和癌症的灵敏度较低。对于不愿意接受结肠镜检查的患者，它似乎仍然是一种足够的替代方法。传统的结肠镜检查仍然是结直肠癌筛查的金标准，并用于评估所有筛查计划的阳性筛查检测结果。它是唯一一种具有去除检测到的息肉和获取活检标本能力的方法。
