Max-Planck-Institut für Dynamik komplexer technischer Systeme, D-39106 Magdeburg, Germany.
J Chromatogr A. 2011 Apr 22;1218(16):2232-9. doi: 10.1016/j.chroma.2011.02.021. Epub 2011 Feb 17.
A new integrated 3-zone simulated moving bed (SMB) concept with internal racemization reaction was suggested recently for the production of single enantiomers from racemic mixtures [1,2]. The process utilizes an internal gradient to trigger the racemization within a single zone. It can deliver the pure enantiomer and outperforms conventional technologies. In this contribution, the concept is validated experimentally for the separation of a model system compound. The results demonstrate that the new concept is capable of producing a single enantiomer with purity, yield and conversion of 100%.
最近提出了一种新的集成三区模拟移动床（SMB）概念，该概念具有内部外消旋反应，用于从外消旋混合物中生产单一对映异构体[1,2]。该工艺利用内部梯度在单个区域内引发外消旋反应。它可以提供纯对映异构体，优于传统技术。在本贡献中，该概念通过实验验证了用于分离模型体系化合物。结果表明，该新概念能够以 100%的纯度、收率和转化率生产单一对映异构体。
