Suchocka-Capuano Agnieszka, Brédart Anne, Dolbeault Sylvie, Rouic Livia Lumbroso-Le, Lévy-Gabriel Christine, Desjardins Laurence, Flahault Cécile, Bungener Catherine
Institut Curie, unité de psycho-oncologie, France.
Bull Cancer. 2011 Feb;98(2):97-107. doi: 10.1684/bdc.2011.1300.
Treatments for choroidal melanoma (CM) generate largely unknown consequences on the level of the quality of life (QoL) and psychological state. Prospective published work is relatively rare and their results are not consistent. The objective of this study is to describe the QoL and psychological state's evolution in patients treated by conservative treatment for CM.
Sixty-nine patients treated for CM by conservative treatment (proton beam irradiation or iodine plaques). QoL (EORTC-QLQ-C30 + QLQ-OPT-30), anxiety and depression (HADS, STAI-B-trait).
Prospective study comprising four evaluations T0: before the beginning of the treatment, T1: one month, T2: six month, T3: one year after the treatment. The preliminary results of the first two evaluations showed that the level of the QoL remained relatively good and stable with an exception for the social functioning, which decreased after the treatment. More than half of the patients had a moderated rate of anxiety before the beginning of the treatment, which decreased significantly a month later. The depressive symptoms were lower and remained stable one month after the treatment. These results confirmed the importance of exploration and screening the fear of cancer recurrence among choroidal melanoma patients.
脉络膜黑色素瘤（CM）的治疗对生活质量（QoL）和心理状态产生的后果在很大程度上尚不清楚。前瞻性发表的研究相对较少，且结果并不一致。本研究的目的是描述接受CM保守治疗的患者的生活质量和心理状态的演变。
69例接受CM保守治疗（质子束照射或碘斑敷贴）的患者。生活质量（欧洲癌症研究与治疗组织生活质量问卷核心30项+眼癌特异性模块30项）、焦虑和抑郁（医院焦虑抑郁量表、特质焦虑量表B）。
前瞻性研究，包括四次评估：T0：治疗开始前，T1：治疗后1个月，T2：治疗后6个月，T3：治疗后1年。前两次评估的初步结果显示，生活质量水平相对良好且稳定，但社会功能除外，其在治疗后下降。超过一半的患者在治疗开始前焦虑程度适中，1个月后显著下降。抑郁症状较低，治疗1个月后保持稳定。这些结果证实了在脉络膜黑色素瘤患者中探索和筛查对癌症复发恐惧的重要性。
