Gollrad Johannes, Rabsahl Christopher, Joussen Antonia M, Stroux Andrea, Budach Volker, Böhmer Dirk, Böker Alexander
Department of Radiation Oncology and Radiotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Department of Ophthalmology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Ocul Oncol Pathol. 2022 Jun;8(2):110-119. doi: 10.1159/000520524. Epub 2021 Nov 8.
Proton beam therapy is an established primary treatment for patients with nonmetastasized uveal melanoma. Adjuvant local interventions, like intravitreal injections or surgery, were shown to improve long-term eye preservation; however, their impact on the patient's quality of life (QOL) remains unknown.
In a post-radiotherapeutic follow-up, we prospectively collected data on QOL, visual acuity, and interventional adjuvant procedures. QOL was measured with QOL-C30 questionnaire and quality of life questionnaire OPT30 at baseline, and at 3 and 12 months after proton therapy. Patients were grouped by the type of adjuvant treatment. The impact on QOL was analyzed by comparing changes in the mean score values and visual acuity for different interventional subgroups, with generalized linear mixed models and Wilcoxon signed-rank tests.
We received 108 (100%) and 95 (88.0%) questionnaires at 3 and 12 months post-therapy, respectively. Adjuvant interventions included observation ( = 61, 56.5%), intravitreal injections ( = 17, 15.7%), and an intraocular surgical procedure ( = 30, 27.8%). In the latter group, several QOL items significantly declined after the 3-month adjuvant interval, but they partially recovered at the 12-month follow-up. In all adjuvant-intervention groups, global QOL scores returned to baseline levels at 12 months.
Posttreatment adjuvant interventions had no long-lasting effects on QOL in patients with uveal melanoma.
质子束疗法是未转移的葡萄膜黑色素瘤患者既定的主要治疗方法。辅助性局部干预措施，如玻璃体内注射或手术，已被证明可提高长期眼球保留率；然而，它们对患者生活质量（QOL）的影响尚不清楚。
在放射治疗后的随访中，我们前瞻性地收集了有关生活质量、视力和辅助性干预程序的数据。在基线时以及质子治疗后3个月和12个月，使用QOL-C30问卷和OPT30生活质量问卷测量生活质量。患者按辅助治疗类型分组。通过使用广义线性混合模型和Wilcoxon符号秩检验比较不同干预亚组的平均得分值和视力变化，分析对生活质量的影响。
治疗后3个月和12个月，我们分别收到了108份（100%）和95份（88.0%）问卷。辅助性干预措施包括观察（n = 61，56.5%）、玻璃体内注射（n = 17，15.7%）和眼内手术程序（n = 30，27.8%）。在后一组中，几个生活质量项目在3个月的辅助间隔后显著下降，但在12个月的随访时部分恢复。在所有辅助干预组中，整体生活质量得分在12个月时恢复到基线水平。
治疗后的辅助干预措施对葡萄膜黑色素瘤患者的生活质量没有长期影响。
