School of Medical Sciences, University of Aberdeen, Aberdeen, Scotland, UK.
J Gerontol A Biol Sci Med Sci. 2011 Jun;66(6):620-6. doi: 10.1093/gerona/glr025. Epub 2011 Mar 7.
Sarcopenia is the loss of muscle size and function during ageing. The aim of this study was to test whether serum concentrations of myostatin and interacting proteins (GASP-1, FLRG, and follistatin) differed between young and elderly sarcopenic men. Isometric knee extensor maximal voluntary contraction and quadriceps cross-sectional area (magnetic resonance imaging measurement) were significantly higher in young (22 ± 2 years; 266 ± 54 N/m; 8,686 ± 1,154 mm(2)) than in mildly sarcopenic (69 ± 3 years; 183 ± 17 N/m; 6,621±718 mm(2)) and severely sarcopenic men (76 ± 6 years; 127 ± 23 N/m; 5,846 ± 591 mm(2)), respectively (p ≤ .01 for all comparisons). There was a trend (p = .06) toward higher FLRG in young (20 ± 8 ng/mL) than in mildly (15 ± 6 ng/mL) and severely sarcopenic men (17 ± 8 ng/mL). Myostatin, follistatin, GASP-1, tumor necrosis factor α, and interleukin-6 did not differ significantly. Insulin-like growth factor-1 and free testosterone were both significantly lower in sarcopenic men (p < .001). This suggests that altered serum concentrations of myostatin and myostatin-interacting proteins are not contributing to sarcopenia with the possible exception of FLRG.
肌肉减少症是指随着年龄增长肌肉大小和功能的丧失。本研究旨在测试血清中肌肉生长抑制素及其相互作用蛋白（GASP-1、FLRG 和卵泡抑素）的浓度是否在年轻和老年肌肉减少症男性中存在差异。等长膝关节伸肌最大随意收缩和股四头肌横截面积（磁共振成像测量）在年轻（22 ± 2 岁；266 ± 54 N/m；8686 ± 1154 mm²）男性中显著高于轻度（69 ± 3 岁；183 ± 17 N/m；6621 ±718 mm²）和重度肌肉减少症男性（76 ± 6 岁；127 ± 23 N/m；5846 ± 591 mm²）（所有比较均为 p ≤.01）。FLRG 在年轻男性（20 ± 8 ng/mL）中略高于轻度（15 ± 6 ng/mL）和重度肌肉减少症男性（17 ± 8 ng/mL）（p =.06，有趋势）。肌肉生长抑制素、卵泡抑素、GASP-1、肿瘤坏死因子-α和白细胞介素-6 没有显著差异。胰岛素样生长因子-1 和游离睾酮在肌肉减少症男性中均显著降低（p <.001）。这表明，肌肉生长抑制素和肌肉生长抑制素相互作用蛋白的血清浓度改变可能不是肌肉减少症的原因，除了 FLRG 可能例外。
