The Zucker Hillside Hospital, Psychiatry Research, North Shore – Long Island Jewish Health System, Glen Oaks, NY 11004, USA.
Soc Cogn Affect Neurosci. 2012 Mar;7(3):289-95. doi: 10.1093/scan/nsr007. Epub 2011 Mar 7.
The error-related negativity (ERN) is an event-related potential (ERP) that indexes error monitoring. Research suggests that the ERN is increased in internalizing disorders, such as depression and anxiety. Although studies indicate that the ERN is insensitive to state-related fluctuations in anxiety, few studies have carefully examined the effect of state-related changes in sadness on the ERN. In the current study, we sought to determine whether the ERN would be altered by a sad mood induction using a between-subjects design. Additionally, we explored if this relationship would be moderated by individual differences in neuroticism-a personality trait related to both anxiety and depression. Forty-seven undergraduate participants were randomly assigned to either a sad or neutral mood induction prior to performing an arrow version of the flanker task. Participants reported greater sadness following the sad than neutral mood induction; there were no significant group differences on behavioral or ERP measures. Across the entire sample, however, participants with a larger increase in sad mood from baseline to post-induction had a larger (i.e. more negative) ERN. Furthermore, this effect was larger among individuals reporting higher neuroticism. These data indicate that neuroticism moderates the relationship between the ERN and changes in sad mood.
错误相关负向波（ERN）是一种事件相关电位（ERP），用于反映错误监测。研究表明，ERN 在诸如抑郁和焦虑等内化障碍中增加。尽管研究表明，ERN 对焦虑的状态相关波动不敏感，但很少有研究仔细检查悲伤的状态相关变化对 ERN 的影响。在当前的研究中，我们试图通过使用被试间设计来确定悲伤情绪诱发是否会改变 ERN。此外，我们还探讨了这种关系是否会受到神经质的个体差异的调节，神经质是一种与焦虑和抑郁都有关的人格特质。47 名本科生被随机分配到悲伤或中性情绪诱发组，然后再执行箭头版本的 Flanker 任务。与中性情绪诱发相比，悲伤情绪诱发后参与者报告的悲伤感更强；在行为或 ERP 测量方面，两组没有显著差异。然而，在整个样本中，悲伤情绪从基线到诱发后的增加幅度较大的参与者的 ERN 更大（即更负）。此外，这种影响在神经质较高的个体中更大。这些数据表明，神经质调节了 ERN 与悲伤情绪变化之间的关系。
