Department of Clinical Biochemistry and Immunology, Leeds Teaching Hospitals Trust, Leeds LS13EX, UK.
Ann Clin Biochem. 2011 Mar;48(Pt 2):186-9. doi: 10.1258/acb.2010.010170. Epub 2011 Mar 7.
Hepatic haemangioendothelioma is a rare vascular tumour in infants and may be associated with a unique form of thyroid function abnormalities. Hepatic haemangioendotheliomata is capable of producing an excess of the thyroid hormone inactivating enzyme, type 3 iodothyronine deiodinase. The increased enzyme activity leads to rapid degradation of thyroid hormones, resulting in frank hypothyroidism. We report a case of a three-month-old neonate with multiple hepatic haemangioendotheliomata and associated hypothyroidism. The patient required increasing doses of thyroid hormone.
肝血管内皮细胞瘤是一种罕见的婴儿血管肿瘤，可能与一种独特的甲状腺功能异常有关。肝血管内皮细胞瘤能够产生过多的甲状腺激素失活酶，即 3 型碘甲状腺原氨酸脱碘酶。这种酶活性的增加导致甲状腺激素的迅速降解，导致明显的甲状腺功能减退症。我们报告了一例三个月大的新生儿患有多个肝血管内皮细胞瘤和相关的甲状腺功能减退症。该患者需要增加甲状腺激素的剂量。
