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甲状腺激素治疗甲状腺功能减退症。

Thyroid hormone therapy for hypothyroidism.

机构信息

Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

Division of Endocrinology, Diabetes, and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

出版信息

Endocrine. 2019 Oct;66(1):18-26. doi: 10.1007/s12020-019-02023-7. Epub 2019 Aug 1.

DOI:10.1007/s12020-019-02023-7
PMID:31372822
Abstract

The purpose of this article will be to review the basics of thyroid hormone therapy, including various thyroid hormone formulations, the institution and monitoring of thyroid hormone therapy, adverse effects of overtreatment, the management of patients with persistent symptoms despite normal thyroid function tests, and potential new innovations in thyroid hormone therapy. The conclusions support the necessity to personalize thyroid hormone replacement therapy in hypothyroid patients.

摘要

本文旨在回顾甲状腺激素治疗的基础知识,包括各种甲状腺激素制剂、甲状腺激素治疗的开始和监测、过度治疗的不良反应、尽管甲状腺功能检查正常但仍有持续症状的患者的管理,以及甲状腺激素治疗的潜在新创新。这些结论支持对甲状腺功能减退症患者进行个体化甲状腺激素替代治疗的必要性。

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Thyroid hormone therapy for hypothyroidism.甲状腺激素治疗甲状腺功能减退症。
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2
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本文引用的文献

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Subclinical Hypothyroidism: A Review.亚临床甲状腺功能减退症:综述。
JAMA. 2019 Jul 9;322(2):153-160. doi: 10.1001/jama.2019.9052.
2
Thyroid hormones treatment for subclinical hypothyroidism: a clinical practice guideline.甲状腺激素治疗亚临床甲状腺功能减退症:临床实践指南。
BMJ. 2019 May 14;365:l2006. doi: 10.1136/bmj.l2006.
3
Physician Choice of Hypothyroidism Therapy: Influence of Patient Characteristics.医师对甲状腺功能减退症治疗的选择:患者特征的影响。
探索甲状腺功能减退与代谢功能障碍相关脂肪性肝病之间的联系:一项英国生物银行队列研究。
Sci Rep. 2025 Feb 25;15(1):6692. doi: 10.1038/s41598-025-91221-7.
4
The association between serum soluble α-Klotho and thyroid profile among adults from NHANES 2007-2012.血清可溶性α-Klotho 与 NHANES 2007-2012 成年人甲状腺参数之间的关联。
BMC Endocr Disord. 2024 Aug 28;24(1):161. doi: 10.1186/s12902-024-01687-1.
5
Multi-omics insight into the metabolic and cellular characteristics in the pathogenesis of hypothyroidism.多组学深入洞察甲状腺功能减退症发病机制中的代谢和细胞特征。
Commun Biol. 2024 Aug 14;7(1):990. doi: 10.1038/s42003-024-06680-x.
6
The Expression of Neurodegeneration-Related Genes in the Hippocampus of Hypothyroid Rats Following Long-Term Potentiation.长期增强后甲状腺功能减退大鼠海马中神经退行性变相关基因的表达
Eurasian J Med. 2024 Feb;56(1):21-26. doi: 10.5152/eurasianjmed.2024.23133.
7
[Ga]Ga-FAPI versus 2-[F]FDG PET/CT in patients with autoimmune thyroiditis: a case control study.[镓]镓标记的纤维连接蛋白活化肽成像(Ga-FAPI)与2-[氟]氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描(2-[F]FDG PET/CT)在自身免疫性甲状腺炎患者中的比较:一项病例对照研究。
EJNMMI Res. 2024 Jul 18;14(1):66. doi: 10.1186/s13550-024-01129-y.
8
The interlink between thyroid autoimmunity and type 1 diabetes and the impact on male and female fertility.甲状腺自身免疫与1型糖尿病之间的联系以及对男性和女性生育能力的影响。
Hormones (Athens). 2024 Sep;23(3):429-437. doi: 10.1007/s42000-024-00563-w. Epub 2024 May 15.
9
Eltroxin and Hesperidin mitigate testicular and renal damage in hypothyroid rats: amelioration of oxidative stress through PPARγ and Nrf2/HO-1 signaling pathway.左旋甲状腺素和橙皮苷减轻甲状腺功能减退大鼠的睾丸和肾脏损伤:通过PPARγ和Nrf2/HO-1信号通路改善氧化应激。
Lab Anim Res. 2024 May 14;40(1):19. doi: 10.1186/s42826-024-00204-8.
10
Tyrosine kinase inhibitor-induced hypothyroidism: mechanism and clinical implications.酪氨酸激酶抑制剂诱导的甲状腺功能减退症:机制及临床意义。
Eur J Clin Pharmacol. 2024 Jun;80(6):827-838. doi: 10.1007/s00228-024-03626-4. Epub 2024 Mar 14.
Thyroid. 2018 Nov;28(11):1416-1424. doi: 10.1089/thy.2018.0325.
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Pathophysiological relevance of deiodinase polymorphism.脱碘酶多态性的病理生理学相关性。
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Diagnostic Accuracy of Real-Time Sonography in Differentiating Diffuse Thyroid Disease From Normal Thyroid Parenchyma: A Multicenter Study.实时超声诊断弥漫性甲状腺疾病与正常甲状腺实质的准确性:多中心研究。
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Severe Hypothyroidism due to the Loss of Therapeutic Efficacy of l-Thyroxine in a Patient with Esophageal Complication Associated with Systemic Sclerosis.一名患有与系统性硬化症相关食管并发症的患者因左甲状腺素治疗效果丧失导致严重甲状腺功能减退。
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Eur Thyroid J. 2017 Jul;6(3):143-151. doi: 10.1159/000469709. Epub 2017 Apr 24.
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Curr Opin Endocrinol Diabetes Obes. 2017 Oct;24(5):356-363. doi: 10.1097/MED.0000000000000355.