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长期口服抑菌治疗后出现的青霉素低敏性无乳链球菌患者分离株中的新型突变。

Novel mutations in a patient isolate of Streptococcus agalactiae with reduced penicillin susceptibility emerging after long-term oral suppressive therapy.

机构信息

Centre Hospitalier Universitaire de Québec and OAHPP, 2705 Laurier Blvd., Quebec City, Quebec G1V4G2, Canada.

出版信息

Antimicrob Agents Chemother. 2011 Jun;55(6):2983-5. doi: 10.1128/AAC.01243-10. Epub 2011 Mar 7.

DOI:10.1128/AAC.01243-10
PMID:21383092
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3101384/
Abstract

Penicillin nonsusceptibility has been demonstrated in group B streptococci (GBS), but there is limited information regarding mechanisms of resistance. We report a case of GBS with reduced susceptibility to penicillin emerging after long-term suppressive oral penicillin therapy for a prosthetic joint infection. Molecular characterization of the isolate before and after long-term penicillin therapy revealed 5 mutations in the ligand-binding regions of PBP1a, -2a, and -2x not previously reported in GBS.

摘要

已经证实 B 组链球菌（GBS）存在青霉素不敏感性，但有关耐药机制的信息有限。我们报告了一例 GBS 病例，该病例在长期抑制性口服青霉素治疗假体关节感染后出现青霉素低敏性。在长期青霉素治疗前后对分离株进行分子特征分析，发现 PBP1a、-2a 和 -2x 的配体结合区域有 5 个突变，这些突变以前在 GBS 中没有报道过。

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