Department of Statistics and Operations Research, Tel Aviv University, Tel Aviv 69978, Israel.
Proc Natl Acad Sci U S A. 2011 Sep 13;108 Suppl 3(Suppl 3):15580-7. doi: 10.1073/pnas.1014837108. Epub 2011 Mar 7.
To obtain a perspective on an animal's own functional world, we study its behavior in situations that allow the animal to regulate the growth rate of its behavior and provide us with the opportunity to quantify its moment-by-moment developmental dynamics. Thus, we are able to show that mouse exploratory behavior consists of sequences of repeated motion: iterative processes that increase in extent and complexity, whose presumed function is a systematic active management of input acquired during the exploration of a novel environment. We use this study to demonstrate our approach to quantifying behavior: targeting aspects of behavior that are shown to be actively managed by the animal, and using measures that are discriminative across strains and treatments and replicable across laboratories.
为了从动物自身的功能角度来了解动物，我们在一些允许动物自行调节行为生长速度的环境中研究动物的行为，以便我们有机会对其即时发展动态进行量化。因此，我们可以发现，老鼠的探索行为由一系列重复的动作组成：范围和复杂度逐渐增加的迭代过程，其假定的功能是对在新环境中探索时获得的输入进行系统的主动管理。我们使用这项研究来展示我们量化行为的方法：针对动物主动管理的行为方面，并使用在不同品系和处理组中具有区分度且在不同实验室中可复制的度量标准。
