Center for Vaccines and Immunity, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA.
Nat Med. 2011 Mar;17(3):252-3. doi: 10.1038/nm0311-252.
Finding mechanisms of viral resistance and new ways to tackle chronic hepatitis will help find a cure for this disease. In ‘Bench to Bedside’, Christopher Walker and Benoît Callendret highlight studies showing that overcoming immune exhaustion during chronic infection by blocking several inhibitory pathways of T cells may restore an adequate immune response. In ‘Bedside to Bench’, Lawrence Corey, Joshua Schiffer and John Scott discuss recent advances in antiviral therapy with protease inhibitors and the findings of a mathematical model that predicts possible single and double mutations prior to antiviral therapy.
寻找病毒耐药机制和解决慢性肝炎的新方法将有助于找到这种疾病的治愈方法。在“从实验室到临床”部分，Christopher Walker 和 Benoît Callendret 强调了一些研究，这些研究表明，通过阻断 T 细胞的几个抑制途径来克服慢性感染期间的免疫衰竭，可能会恢复适当的免疫反应。在“从临床到实验室”部分，Lawrence Corey、Joshua Schiffer 和 John Scott 讨论了蛋白酶抑制剂抗病毒治疗的最新进展，以及一个数学模型的发现，该模型预测了抗病毒治疗前可能出现的单突变和双突变。
