Research Institute at Nationwide Children’s Hospital, Columbus, Ohio, USA.
Adv Virus Res. 2010;78:43-86. doi: 10.1016/B978-0-12-385032-4.00002-1.
The hepatitis C virus (HCV) is a global public health problem affecting approximately 2% of the human population. The majority of HCV infections (more than 70%) result in life-long persistence of the virus that substantially increases the risk of serious liver diseases, including cirrhosis and hepatocellular carcinoma. The remainder (less than 30%) resolves spontaneously, often resulting in long-lived protection from persistence upon reexposure to the virus. To persist, the virus must replicate and this requires effective evasion of adaptive immune responses. In this review, the role of humoral and cellular immunity in preventing HCV persistence, and the mechanisms used by the virus to subvert protective host responses, are considered.
丙型肝炎病毒（HCV）是一个全球性的公共卫生问题，影响了大约 2%的人类人口。大多数 HCV 感染（超过 70%）导致病毒的终身持续存在，大大增加了患严重肝脏疾病的风险，包括肝硬化和肝细胞癌。其余（不到 30%）会自发解决，通常会在再次接触病毒时产生长期的保护作用，防止持续感染。为了持续存在，病毒必须复制，这需要有效地逃避适应性免疫反应。在这篇综述中，考虑了体液和细胞免疫在预防 HCV 持续感染中的作用，以及病毒用来颠覆宿主保护性反应的机制。
