Elm Courtney M L, Wallander Irmina D, Endrizzi Bart, Zelickson Brian D
Zel Skin & Laser Specialists, 4100 West 50th Street, Edina, Minnesota 55424, USA.
Lasers Surg Med. 2011 Feb;43(2):114-21. doi: 10.1002/lsm.21016.
Low-level laser therapy (LLLT) has been shown to induce cellular reactions in nonphotosynthetic cells however skepticism remains regarding efficacy at the clinical level. The purpose of this study was to evaluate the efficacy of LLLT independent of liposuction. Additionally, a weight loss supplement (Curva™, Santa Barbra Medical Innovations, Santa Barbra, CA) was evaluated. This clinical trial evaluates the effectiveness of the Erchonia EML Laser (Zerona™ System, Santa Barbra Medical Innovations) for non-invasive fat reduction and body contouring in a split-body clinical evaluation.
Five subjects were enrolled and completed the study. Subjects had a body mass index (BMI) of less than or equal to 29 kg/m(2) and satisfied the set inclusion criteria. Participants were randomly assigned to receive low-level laser treatments on one side of the body three times per week for 2 weeks. One group took the weight loss supplement and was also treated with the laser. Subject satisfaction questionnaires, physician blinded photo evaluation, circumference measurements and ultrasound measurements were utilized to evaluate efficacy.
Circumference measurements revealed no statistically significant reduction at either 7 days or 1 month post-treatment. One month following treatment the greatest circumference reduction overall was 0.5 ± 0.3 inches. Ultrasound measurements also did not reveal statistically significant reduction in fat layer thickness (P > 0.5). Evaluation by three blinded dermatologists resulted in average correct photo identification of 51.1%. Results reflect little clinical difference between post-treatment and baseline images. Three subjects recording a "dissatisfied" rating on satisfaction questionnaires and all subjects reported the effects of the treatment were less than expected. Subjects who took the weight loss supplement had no greater circumference reduction or identifiable clinical outcome.
This small study demonstrates to the authors that there needs to be more evidence to show clinical circumferential reduction before LLLT can be recommended as an effective therapeutic option.
低强度激光疗法（LLLT）已被证明可在非光合细胞中诱导细胞反应，然而在临床层面其疗效仍存在疑虑。本研究的目的是评估不依赖抽脂的低强度激光疗法的疗效。此外，还对一种减肥补充剂（Curva™，圣巴巴拉医疗创新公司，加利福尼亚州圣巴巴拉）进行了评估。这项临床试验在一项分体临床评估中，评估了Erchonia EML激光（Zerona™系统，圣巴巴拉医疗创新公司）用于非侵入性减脂和身体塑形的有效性。
招募了5名受试者并完成了研究。受试者的体重指数（BMI）小于或等于29 kg/m²，且符合设定的纳入标准。参与者被随机分配，每周在身体一侧接受3次低强度激光治疗，共2周。一组服用减肥补充剂并同时接受激光治疗。使用受试者满意度问卷、医生盲法照片评估、周长测量和超声测量来评估疗效。
周长测量显示，治疗后7天或1个月时均无统计学显著减少。治疗后1个月，总体最大周长减少为0.5±0.3英寸。超声测量也未显示脂肪层厚度有统计学显著减少（P>0.5）。三位盲法皮肤科医生的评估结果显示，照片正确识别的平均准确率为51.1%。结果表明治疗后图像与基线图像之间几乎没有临床差异。三名受试者在满意度问卷上给出了“不满意”的评分，所有受试者都报告治疗效果低于预期。服用减肥补充剂的受试者在周长减少或可识别的临床结果方面没有更大改善。
这项小型研究向作者表明，在低强度激光疗法被推荐为一种有效的治疗选择之前，需要更多证据来证明其在临床上周长减少的效果。
