Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, Korea.
Department of Plastic and Reconstructive Surgery, Soonchunhyang University Bucheon Hospital, 170 Jomaru-ro, Bucheon-si, Gyeonggi-do, Korea.
Lasers Med Sci. 2022 Feb;37(1):505-512. doi: 10.1007/s10103-021-03288-z. Epub 2021 Apr 2.
The aim of this study was to evaluate the safety and efficacy of combined 1060-nm diode laser and 635-nm low-level laser therapy (LLLT) device for non-invasive reduction of the abdominal and submental fat. Forty-two healthy subjects received single laser treatment on both the abdomen and submental area. Ultrasound images measuring the thickness of abdominal and submental fat were taken at baseline, follow-up at 4, 8, and 12 weeks after treatment. Waist circumference and body weight were also measured at all visits. Adverse events were recorded at all visits. Subjects completed a satisfaction questionnaire at the end of the trial. Twelve weeks after a single treatment with the investigational device, ultrasound images showed statistically significant (P < 0.0001) reductions in abdominal and submental fat by 18.62 and 26.4%, respectively. In addition, significant (P < 0.0001) reduction in waist circumference was observed. Ninety-six percent of subjects rated that they were satisfied. Noted side effects were transient mild to moderate tenderness which subsided within 1 to 3 weeks. No serious treatment-related adverse events were reported. The dual wavelength device combining 1060-nm diode laser with 635-nm LLLT was safe and effective for non-invasive reduction of both abdominal and submental fat.
本研究旨在评估 1060nm 半导体激光与 635nm 低水平激光治疗（LLLT）联合设备在无创性减少腹部和颏下脂肪方面的安全性和有效性。42 名健康受试者在腹部和颏下区域接受单次激光治疗。在治疗后 4、8 和 12 周，测量腹部和颏下脂肪厚度的超声图像。所有就诊时均测量腰围和体重。所有就诊时均记录不良事件。试验结束时，受试者完成满意度问卷。单次治疗 12 周后，超声图像显示腹部和颏下脂肪分别显著减少 18.62%和 26.4%（P < 0.0001）。此外，腰围也明显减少（P < 0.0001）。96%的受试者表示满意。注意到的副作用是短暂的轻度到中度压痛，在 1 至 3 周内消退。未报告严重与治疗相关的不良事件。结合 1060nm 半导体激光与 635nm LLLT 的双波长设备在无创性减少腹部和颏下脂肪方面是安全有效的。
