Smith M D, Roberts-Thomson P J
Department of Clinical Immunology, Flinders Medical Centre, Adelaide, South Australia.
Ann Rheum Dis. 1990 Feb;49(2):81-7. doi: 10.1136/ard.49.2.81.
Expression of major histocompatibility complex (MHC) class II and other lymphocyte activation markers on peripheral blood and synovial fluid T lymphocytes from patients with rheumatoid arthritis (RA), psoriatic arthritis, and Reiter's syndrome were measured and the mean fluorescence intensities of these antigens were assessed. Increased expression of MHC class II antigens of synovial fluid T lymphocytes is not unique to RA, though it is quantitatively greater on RA synovial fluid T cells. There was less expression of other lymphocyte activation markers (4F2, transferin receptor) and a marked discordance between the expression of these markers and the interleukin 2 receptor (IL2r). Synovial fluid T lymphocytes contain a subpopulation of larger cells expressing MHC class II and other lymphocyte activation antigens with the exception of the IL2r. Mean fluorescence intensity of CD3 and CD4 antigens on synovial fluid T lymphocytes was decreased in all three patient groups, suggesting prior in vivo exposure of synovial fluid T lymphocytes to an unknown antigen.
对类风湿性关节炎（RA）、银屑病关节炎和赖特综合征患者外周血及滑液T淋巴细胞上主要组织相容性复合体（MHC）II类分子和其他淋巴细胞活化标志物的表达进行了检测，并评估了这些抗原的平均荧光强度。滑液T淋巴细胞上MHC II类抗原表达增加并非RA所特有，尽管在RA滑液T细胞上其表达量更大。其他淋巴细胞活化标志物（4F2、转铁蛋白受体）的表达较少，且这些标志物与白细胞介素2受体（IL2r）的表达之间存在明显不一致。滑液T淋巴细胞包含一个较大细胞的亚群，这些细胞表达MHC II类分子和其他淋巴细胞活化抗原，但不包括IL2r。在所有三个患者组中，滑液T淋巴细胞上CD3和CD4抗原的平均荧光强度均降低，提示滑液T淋巴细胞先前在体内接触过未知抗原。
