Bertouch J V, Roberts-Thomson P J, Brooks P M, Bradley J
J Rheumatol. 1984 Dec;11(6):754-9.
Lymphocyte subsets defined by monoclonal antibodies, C reactive protein (CRP), immune complexes (IC), rheumatoid factor (RF), C3, C4 and neutrophil and lymphocyte numbers were measured in synovial fluid (SF) and blood samples from 11 patients with rheumatoid arthritis. SF showed an increased percentage of T cells, Ia+ cells and OKT8+ cells and a reduced percentage of B cells and OKT4+ cells, when compared with blood. Reduced levels of CRP, RF, C3 and C4 were found in SF compared with blood. Comparisons between cellular subsets and other indices in SF revealed a positive correlation between neutrophil numbers and IC, CRP, and RF with a negative correlation between neutrophil numbers and numbers of T cells and OKT8+ cells. A similar negative correlation was found in blood between OKT8+ cells and both CRP and RF. These results indicate an association between increasing disease activity and a lack of suppressor/cytotoxic cells in both circulating and intraarticular compartments. An additional important finding was the lack of correlation of Ia+ cells in both SF and blood with neutrophil numbers, CRP, IC, C3 and C4 or RF.
对11例类风湿性关节炎患者的滑液（SF）和血液样本进行检测，测定了单克隆抗体定义的淋巴细胞亚群、C反应蛋白（CRP）、免疫复合物（IC）、类风湿因子（RF）、C3、C4以及中性粒细胞和淋巴细胞数量。与血液相比，滑液中T细胞、Ia +细胞和OKT8 +细胞的百分比增加，B细胞和OKT4 +细胞的百分比降低。与血液相比，滑液中CRP、RF、C3和C4水平降低。滑液中细胞亚群与其他指标之间的比较显示，中性粒细胞数量与IC、CRP和RF呈正相关，而中性粒细胞数量与T细胞和OKT8 +细胞数量呈负相关。在血液中，OKT8 +细胞与CRP和RF之间也发现了类似的负相关。这些结果表明，疾病活动增加与循环和关节内区域抑制性/细胞毒性细胞缺乏之间存在关联。另一个重要发现是，滑液和血液中的Ia +细胞与中性粒细胞数量、CRP、IC、C3、C4或RF均无相关性。
