先天性心脏病中的骨形态发生蛋白信号传导：新进展与未来方向
BMP signaling in congenital heart disease: new developments and future directions.
作者信息
Wang Jun, Greene Stephanie B, Martin James F
机构信息
Institute of Biosciences and Technology, Texas A&M System Health Science Center, 2121 W. Holcombe Blvd., Houston, TX 77030, USA.
出版信息
Birth Defects Res A Clin Mol Teratol. 2011 Jun;91(6):441-8. doi: 10.1002/bdra.20785. Epub 2011 Mar 7.
Abstract
Congenital heart malformations are the most common of all congenital human birth anomalies. During the past decade, research with zebrafish, chick, and mouse models have elucidated many fundamental genetic pathways that govern early cardiac patterning and differentiation. This review highlights the roles of the bone morphogenetic protein (BMP) signaling pathway in cardiogenesis and how defective BMP signals can disrupt the intricate steps of cardiac formation and cause congenital heart defects.
摘要
先天性心脏畸形是人类所有先天性出生缺陷中最常见的。在过去十年中，对斑马鱼、鸡和小鼠模型的研究阐明了许多控制早期心脏模式形成和分化的基本遗传途径。本综述重点介绍了骨形态发生蛋白（BMP）信号通路在心脏发生中的作用，以及有缺陷的BMP信号如何破坏心脏形成的复杂步骤并导致先天性心脏缺陷。
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